Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Background The EVI1 gene (3q26) codes for a zinc finger transcription factor with important roles in both mammalian development and leukemogenesis.Over-expression of EVI1 through either 3q26 rearrangements, MLL fusions, or other unknown mechanisms confers a poor prognosis in acute myeloid leukemia.Design and Methods We analyzed the prevalence and p

read more


The challenge of diagnosing Plasmodium ovale malaria in travellers: report of six clustered cases in french soldiers returning from West Africa

Abstract Background Plasmodium ovale is responsible for 5% of imported malaria in French travellers.The clinical and biological features of six clustered cases of P.ovale malaria in an army unit of 62 French soldiers returning from the Ivory Coast are reported.Case report All patients were symptomatic and developed symptoms on average 50 days after

read more